Blog
Welcome to our blog! Explore educational content ranging from innovative treatments to insightful medical knowledge, curated by Dr. Rezaian, a specialist in Rheumatology and Internal Medicine.
Breakthrough in Gout Treatment: PRX-115 Shows 12-Week Uric Acid Reduction with a Single Dose
Summary: Prolonged Plasma Urate-Lowering with PRX-115 This study explores a new medication, PRX-115, designed to lower uric acid levels in the blood. PRX-115 is a modified enzyme (PEGylated uricase) that breaks down uric acid, aimed at treating severe gout cases where...
Protecting Joints from Within: How Liraglutide Outperforms Dexamethasone in Osteoarthritis
This study explores the use of intra-articular (IA) liraglutide (LIRA), a glucagon-like peptide-1 (GLP-1) analog, for treating osteoarthritis (OA), a common age-related disease that causes chronic pain and restricts mobility. Current treatments, like corticosteroids...
Breaking Down Kidney Inflammation: Single-Cell Analysis of Immune Cells in ANCA Vasculitis
This study investigates the role of B and T cells in kidney biopsies from patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), an autoimmune disease that primarily affects small blood vessels, leading to severe complications in organs...
Bimekizumab: Sustained Relief from Ankylosing Spondylitis Symptoms for 5 Years
The study explored the long-term safety and effectiveness of Bimekizumab (BKZ), a monoclonal antibody designed to block two proteins involved in inflammation, IL-17A and IL-17F. This dual inhibition helps control the excessive inflammation seen in ankylosing...
Tofacitinib Shows Greater Effectiveness in Ankylosing Spondylitis Patients with High CRP Levels
This article presents a post hoc analysis of how baseline (BL) C-Reactive Protein (CRP) levels affect the efficacy and safety of Tofacitinib, a medication used to treat Ankylosing Spondylitis (AS). Tofacitinib is a Janus kinase inhibitor, a type of drug that helps...
Deucravacitinib Delivers Significant Pain Relief for Psoriatic Arthritis Patients in Phase 2 Trial
The article reports on the findings from a Phase 2 clinical trial that investigated the effectiveness of Deucravacitinib, a selective Tyrosine Kinase 2 (TYK2) inhibitor, in reducing pain in patients with active Psoriatic Arthritis (PsA). PsA is a chronic inflammatory...
When Back Pain Strikes After 45: A Closer Look at Axial Spondyloarthritis
The article you referenced explores the occurrence of axial spondyloarthritis (axSpA) in patients who begin experiencing chronic low back pain after the age of 45, a group that is often less studied compared to younger patients. The researchers aimed to understand the...
Serositis Showdown: Rheumatoid Arthritis vs. Psoriatic Arthritis – Who Suffers More from Pleuropericarditis?
This study focused on comparing the frequency of serositis, which refers to inflammation of the lining around the heart (pericarditis) and lungs (pleuritis), between patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA). These conditions are types of...
The Hidden Link: How High hs-CRP Levels Signal Future Psoriatic Arthritis
The study titled “Higher Levels of High-sensitivity CRP Are Associated with Future Risk of Developing Psoriatic Arthritis Among Patients with Psoriasis” investigates whether high levels of high-sensitivity C-Reactive Protein (hs-CRP), a marker of inflammation in the...
Breaking New Ground: Anti-CCP3 as a Predictor of Arthritis in CCP2-Negative Patients
This study explored whether testing for anti-CCP3 antibodies in people who have musculoskeletal (MSK) symptoms but tested negative for anti-CCP2 antibodies could help predict the development of inflammatory arthritis (IA) or rheumatoid arthritis (RA). A total of 469...
Meet The Author
M M Rezaian, MD
Rheumatology
Dr. Rezaian, who has dedicated over thirty years to the practice of Rheumatology, focuses on the utilization of biologic therapies for treating rheumatic diseases, the study of Spondyloarthropathy, and the innovative field of Telemedicine. He is connected with the WVU Berkeley Medical Center in Martinsburg, West Virginia.